Abstract
BackgroundCurrently, there are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). The results, however, are inconsistent. Therefore, the aim of this study was to estimate the relationship between maternal serum inflammatory indicators and PTB in a nested case-control (NCC)study.MethodsA NCC study was conducted by Guangxi Birth Cohort Study which enrolled a total of 6203 pregnant women between 50/7 and 346/7 weeks of gestational age (wGA) from six cities in China between 2015 and 2016. There were 206women who delivered preterm (< 370/7 wGA), and 412 women who delivered term birth, those women were matched by maternal age, birth place, gender of infants, and wGA at blood collection.The inflammatory indicators were quantified by immunoturbidimetric methods.ResultsHighest quartile concentrations of all inflammatory indicators were determined versus median. After adjusting for maternal age, high levels of CRP (CRP > 16.60 mg/L) are related to the risk of PTB (OR = 2.16, 95% CI: 1.02–4.56, p = 0.044) in the first trimester. The association of C3 was extremely related to those who delivered PTB (OR = 2.53, 95% CI: 1.14–5.64, p = 0.023) in the first trimester. Moreover, no significant associations were found in C4 (p = 0.079) and ferritin (p = 0.067) between PTB.ConclusionsElevated concentrations of CRP and C3 in the first trimester were associated with increased risk of PTB. Inflammatory indicators may act a pivotal part in early diagnosis and prognosis of PTB.
Highlights
There are many studies researched the associations between maternal serum inflammatory indicators and preterm birth (PTB)
We evaluated the associations between maternal serum levels of C-reactive protein (CRP), C3, C4, ferritin and the risk of PTB by using conditional logistic regression
PTB was observed in 345 women, and 4747 had normal term birth (TB)
Summary
There are many studies researched the associations between maternal serum inflammatory indicators (i.e. ferritin, C-reactive protein [CRP], C3 and C4) and preterm birth (PTB). Preterm birth (PTB), an abnormal pregnancy status, defined as delivery before 37 weeks of gestation [1]. It is a major cause of mortality of premature infants and can result in a series of long-term complications in survivors. Huang et al BMC Pregnancy and Childbirth (2020) 20:131 and human immunodeficiency virus have been correlative with increased risk of PTB [6]. More accurate methods to identify women at risk of PTB during pregnancy and sufficiently early in gestation are needed to allow clinical intervention
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