Abstract
To see the present scenario of blood lead (BPb) levels of Silver Jewellery Workers (SJW) and its effects on haematological and heme biosynthesis parameters. Forty-two SJW of having an age range of 20-45 years were included for this study and compared with 50 healthy male subjects of the same age. Blood lead, RBC δ- aminolevulinic acid dehydratase (δ-ALDH), urinary δ- aminolevulinic acid (U- δ-ALA), urinary porphobilinogen (U-PBG) and haematological parameters were measured. Blood lead level of silver jewellery workers was significantly elevated (p<0.001, 325%) and non-activated δ-ALAD (p<0.01), activated δ-ALAD (p<0.05) were notably reduced and the ratio of A/NA δ-ALAD (p<0.01) was considerably enlarged in SJW as compared to control group subjects. Urinary excretion of δ-ALA (p<0.001) and PBG (p<0.001) levels were extensively increased in SJW as compared to subjects from the control group. Hb (p<0.001), PCV (p<0.001), MCV (p<0.001), MCH (p<0.05) and RBC (p<0.001) were notably reduced in SJW, while total WBC count (p<0.001, 29.8%) was considerably elevated as compared to subjects from the control group. Conclusions: Increased BPb level in SJW indicates the more absorption of lead from the GIT, which inhibits heme biosynthesis, and alters haematological parameters.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Research in Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.