Elements of Immunoglobulin E Network Associate with Aortic valve Area in Patients with Acquired Aortic Stenosis.

Daniel P Potaczek,Ko Okumura,Chiharu Nishiyama,Ewa Wypasek,Aleksandra Przytulska-Szczerbik,Artur Jurczyszyn,Anetta Undas,Stanisława Bazan-Socha

doi:10.3390/biomedicines9010023

Abstract

Allergic mechanisms are likely involved in atherosclerosis and its clinical presentations, such as coronary artery disease (CAD). It has been previously reported that CAD severity associates with serum levels of immunoglobulin E (IgE), the molecule that, along with its high-affinity receptor (FcԑRI), plays a central role in allergic reactions. Considering multiple pathophysiological similarities between atherosclerosis and acquired aortic (valve) stenosis (AS), we speculated that allergic pathways could also contribute to the AS mechanisms and grading. To validate this hypothesis, we first checked whether total serum IgE levels associate with echocardiographic markers of AS severity. Having found a positive correlation between serum IgE and aortic valve area (AVA), we further speculated that also total IgE-determining genetic polymorphisms in FCER1A, a locus encoding an allergen-biding FcԑRI subunit, are related to acquired AS severity. Indeed, the major allele of rs2251746 polymorphism, known to associate with higher IgE levels, turned out to correlate with larger AVA, a marker of less severe AS. Our findings surprisingly suggest a protective role of IgE pathways against AS progression. IgE-mediated protective mechanisms in AS require further investigations.

Highlights

A mean or maximum gradient and left ventricular ejection fraction were not associated with total serum immunoglobulin E (IgE), we documented a positive correlation between IgE and aortic valve area (AVA; R = 0.27, P = 0.01; Table 1, Figure 1)
Total serum IgE was not measured in all subjects
The reason between behind this was the design of the study, We found foranalyzed the first time the relationships the elements of the IgE

Summary

Introduction

The immune system plays an essential role in the development and progression of atherosclerosis and related diseases, including coronary artery disease (CAD), peripheral artery disease, and stroke. Network, to the pathogenesis of atherosclerosis [1,2,3]. Previous studies have demonstrated that the severity of CAD associates with total serum IgE levels [6,7,8]. We hypothesized that AS severity may be related to the IgE network. To verify this speculation, we sought to investigate the associations between AS severity and total serum

Results

Discussion

Conclusion