Abstract
Abstract In order to study adenine-amide interactions, 3-(adenin-9-yl)propionamide has been synthesized and its crystal structure examined. The crystals are monoclinic, the space group being P21/a, with unit-cell dimensions of a=25.668 (1), b=8.025 (1), c=4.684 (1) Å, β=103.54 (1)°, and Z=4. The adenine bases are linked along the two-fold screw axis through the hydrogen bonds, N(6)H···N(1) and N(6)H···N(7). The amide group is hydrogen-bonded to N(3) of adjacent adenine moiety, the distance NH···N(3) being 3.055 Å. The model fitting by computer graphics indicates that this binding scheme could be an elementary interaction pattern between the amide group in protein and adenine in the minor groove of double helical DNA.
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