Abstract
A novel straightforward and catalyst-free approach for synthesizing quinoxaline derivatives from sulfoxonium ylides and o-phenylenediamines mediated by elemental sulfur has been described. Due to the simple and mild reaction conditions, the sulfoxonium ylides and o-phenylenediamines decorated with different functional groups furnished moderate to high yields of quinoxaline derivatives and were well tolerated. Finally, large-scale reactions, the synthesis of pyrazines, and some bioactive compounds are used to illustrate the potential utility of the developed approach.
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