ELEMENTAL COMPOSITION OF TISSUES AND TOXICOKINETICS OF ARSENIC AND ANTIMONY ON INTAKE IN MALE WHITE RATS OF THE WISTAR LINE WITH DRINKING WATER

Abstract

The biogeochemical province of antimony and arsenic created in the area of massive sulphide deposits forms a level of their exchange in the biosphere that is different from the usual conditions. These elements along with a number of common properties of the semi-metals have significant features of biological action. The aim of the study was to assess the variability of the elemental composition of the liver tissues of white rats with oral intake of wastewater from the tailings of Komsomolsk gold mine (Kemerovo region) with a high content of antimony and arsenic. The objects of the study were wastewater from the slurry pits of Komsomolsk gold mine (Kemerovo region); liver tissue of white rats of the Wistar line, whole blood, urine, excrements. The contents of sulfur, chlorine, potassium, calcium, titanium, manganese, chromium, iron, nickel, copper, zinc, selenium, bromine, rubidium, strontium, molybdenum, arsenic, mercury, lead, antimony in the tissues of the liver, blood, urine, excrements before priming, after 3 weeks of priming and after 1, 2 and 4 weeks during the recovery period after priming have been determined. It has been established that combined oral 3 weeks intake of arsenic in a dose of 10,0-15,1 µg / kg / day and antimony in a dose of 4,2-6,1 µg / kg / day in male white rats of the Wistar line is accompanied by their accumulation in the liver and blood and the excretion with urine and excrements, the parameters of the toxicokinetics of arsenic indicate its absorption and elimination from the blood about the same rate, whereas in liver, the rate of elimination of arsenic is somewhat higher than the rate of absorption (t 1/2 - 38 and 49 days and constants of elimination and absorption - 0.018 and 0.014, respectively). The predominance of elimination processes over absorption for antimony in the blood (t 1/2 - 12 and 22 days, constants of elimination and absorption – 0.058 and 0.032, respectively) has been established.