Abstract
ObjectivesMarine algae are important sources of nutritionally and pharmacologically important products. Here in the study, nutritional composition and biological activities of a marine red algae Nitophyllum punctatum were assessed. The present study aimed to analyze the nutritional composition and biological effects of the N. punctatum. MethodsThe marine algae N. punctatum was collected, shade dried and extracted using Soxhelet apparatus. The elemental composition was estimated using Atomic Absorption Spectroscopy; the anti-inflammatory effect was determined using Raw 264.7 macrophages. Genotoxicity was assessed by standard methods using Allium cepa root model. ResultsThe elemental composition analysis revealed the presence of essential minerals such as calcium, magnesium, potassium, and iron, indicating the potential nutritional value of the algae. The extract demonstrated significant inhibition of Nitric oxide (NO) production and downregulated the expression of pro-inflammatory cytokines such as TNF-α and IL-6, suggesting its potential as an anti-inflammatory agent. Furthermore, the anti-genotoxic potential of the methanol extract was evaluated using the Allium cepa model, a well-established system for assessing genotoxicity. Onion root tips were treated with various concentrations of the extract, and the chromosomal changes were performed as indicators of genotoxicity. Results indicated a protective effect against Ethyl methyl sulfonate (EMS) induced genotoxicity in onion roots. ConclusionsThe findings suggest that the methanol extract of N. punctatum possesses potent anti-inflammatory and anti-genotoxic properties, which may be attributed to the presence of bioactive compounds. The study highlights the potential pharmacological importance of N. punctatum as a source of natural compounds with anti-inflammatory and anti-genotoxic activities.
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