Abstract
The thyroid is an important hormone regulation organ. Laser induced breakdown spectroscopy (LIBS) is developed to assess iodine and other essential elements in the thyroid (of rats). Subjects are administered 0.05% iodine water for 0, 6, and 12 days before the thyroid is extracted. Pronounced iodine, sodium, calcium, and potassium emissions are observed at approximately 746, 589, 395/422, and 766/770 nm, respectively. Iodine emission is surprisingly highest in 0 day subjects, lowest after 6 days, and recovers by 12 days. This follows the Wolff-Chaikoff effect as ingestion of excess iodine reduces thyroid iodine and iodine is essential for hormone production. LIBS is a promising method for trace elemental analysis of the thyroid.
Highlights
The thyroid is an important endocrine gland located in the neck
We develop Laser induced breakdown spectroscopy (LIBS) to analyze many of the important elements in the rat thyroid in situ, including I, Na, Ca, and K
We demonstrate the hypothesis of Wolff–Chaikoff
Summary
The thyroid is an important endocrine gland located in the neck. It secretes hormones, such as triiodothyronine (T3) and thyroxine (T4), which are crucial for regulating metabolism and protein synthesis [1]. Iodine is a micronutrient that is essential for the production of T3 and T4 [2], which are partially composed of iodine Improper levels of these elements and molecules can lead to a range of thyroid disorders, which include hypo and hyperthyroidism. We develop LIBS to analyze many of the important elements in the rat thyroid in situ, including I, Na, Ca, and K This initial study analyzes the thyroid at the organ level, but long-term, LIBS can be developed to perform cellular level elemental analysis. This will complement molecular analyses of thyroid cells [15,16,17]
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