Abstract
The aim of this article is to present data from recent literature and our own experience with respect to the role of pattern electroretinography (PERG) and photopic negative response (PhNR) in glaucoma diagnosis. The results of these studies show that PERG amplitude reduction is an indicator of conversion to manifest glaucoma and a predictor of increased rate of progression of retinal nerve fiber layer (RNFL) thinning in patients with glaucoma suspicion. PERG and PhNR are capable of detecting decreased retinal function when the results of routine diagnostic examinations are still within normal ranges or borderline. PERG and PhNR may also serve to confirm retinal function improvement. Both tests may also serve as an indicator of well-selected IOP-lowering therapy. In patients suspected of normal-tension glaucoma, PERG may be the only indicator of RGCs dysfunction and may be the diagnostic basis for the inclusion of IOP-lowering therapy.
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