Electrospun Self-Pumping dressing with gastrodin for immunomodulation and rapid healing of diabetic wounds

Abstract

The diabetic wound is often associated with excessive inflammatory exudate, scant neovascularization, and imbalanced macrophage immunomodulation. However, the inflammatory exudate is absorbed by gauze to come into contact with the diabetic wound, which hinders the separation of the inflammatory exudate from the wound without creating effective separation protection. Hence, an electrospun multifunctional self-pumping dressing loading with gastrodin is designed to attenuate inflammation, improve immunomodulation, and promote neovascularization. The absorbent layer and drainage layer of the self-pumping dressing are integrated using electrospinning. The inflammatory exudate in the diabetic wound is unidirectionally drained from the drainage layer to the absorbent layer via the self-pumping structure. In addition, the synergistic effect of the immunomodulatory and anti-inflammatory properties of gastrodin and the self-pumping properties of the self-pumping dressing further promote the rapid healing of diabetic wounds. The diabetic wound healing experiment confirms that the self-pumping dressing loading with gastrodin exhibits the ability to rapidly promote diabetic wound healing within 15 days. The self-pumping dressing with gastrodin can regulate inflammatory exudate in diabetic wounds and promote extremely rapid healing of diabetic wounds, which expands the novel application of gastrodin and self-pumping dressing in the field of biomedical materials.