Electrospun porous La–Sr–Co–Ni–O nanofibers for highly sensitive non-enzymatic glucose detection

Kasci D Pelucarte,Jianguo Wen,Tashi A Hatchell,Yulin Lin,Zhiping Luo,Menuka Adhikari,Shubo Han,Gibin George,Sivasankara Rao Ede

doi:10.1039/d1ma00984b

Kasci D Pelucarte, Jianguo Wen + Show 7 more

Open Access

https://doi.org/10.1039/d1ma00984b

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Abstract

Nonenzymatic glucose biosensors based on electrospun porous La–Sr–Co–Ni–O nanofibers used for clinical, industrial, and environmental applications.

Highlights

Non-enzymatic fast and accurate detection of biological molecules is fascinating because of their potential applications in disease diagnosis and management, biological analysis, food industry, and environmental protection
Enzyme-based glucose biosensors still prevail in market, intrinsic problems remain in an enzymatic glucose sensor, such as low enzyme stability, high environmental dependency, high price, and complicated immobilization procedures, owing to the inadequate stability, denaturation of enzymes, thermal and chemical instability to environmental factors like moisture, pH and temperature[30, 31]
We fabricated porous LSCNO nanofibers with nanosized polycrystalline grains with high crystallinity, which resulted from homogeneous nucleation and the spatial confinement of the nanofibers

Summary

Introduction

Non-enzymatic fast and accurate detection of biological molecules is fascinating because of their potential applications in disease diagnosis and management, biological analysis, food industry, and environmental protection. Nonenzymatic electrochemical glucose biosensors using perovskite oxide have been continuously attracting great attentions due to the growing requirements for diabetes management, food quality control, and bioprocess inspection, monitoring of glucose in various matrixes 26-29. Perovskite oxide non-enzymatic glucose biosensors have shown great advantages, such as high sensitivity, high surface area, porosity, low cost, and flexibility. The calibration sensitivity of 924 A/mM and lower limit of detection (LLOD) of 0.083 mM were obtained This level is much lower than the normal blood glucose level of 3.9−5.6 mM, indicating a potential biomedical application for blood test

Materials

Procedures

Results and Discussion

Conclusions