Abstract
Acceleration of wound healing can be achieved with the use of wound dressings. Through the electrospinning technique, a polymeric scaffold composed of two layers was processed: a gelatin and polyvinylpyrrolidone layer with gentamicin, and a second layer of cellulose acetate. The conditions for the electrospinning process were standardized for voltage parameters, feed flow and the distance from the injector to the collector. Once the values of the main variables for the electrospinning were optimized, a three-hour processing time was established to allow the separation of the material from the collector. The obtained material was characterized by observations on scanning electron microscopy, Fourier transform infrared spectroscopy and thermal analysis; contact angle measurement was performed to evaluate wettability properties, and antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus were evaluated using the Kirby–Bauer test. The obtained fibers that form the bi-layer scaffold present diameters from 100 to 300 nm. The scaffold presents chemical composition, thermal stability, wettability characteristics and antibacterial activity that fulfill the proposal from this study, based on obtaining a scaffold that could be used as a drug delivery vehicle and a wound dressing material.
Highlights
The development of scaffolds suitable for the regeneration of damaged tissues with full recovery of their biological functions has long been an important objective in tissue engineering, and electrospinning is one of the processes that has gained great importance as a proposal for the development of such scaffolds
The PG layer or the ones that occurred in the fibers of cellulose acetate (CA) due to its processing using the PG+GEN
All the fibers processed from the respective solution showed smooth edges without layer as a collector
Summary
The development of scaffolds suitable for the regeneration of damaged tissues with full recovery of their biological functions has long been an important objective in tissue engineering, and electrospinning is one of the processes that has gained great importance as a proposal for the development of such scaffolds Due to their fibrous structure, electrospun materials can serve as a scaffold for the skin cells in the auto-repairing process, and by being permeable to moisture and air, allows for the adequate extraction of extra body fluid from the wound area to avoid infection and maintain a moisturized environment [1,2]. Due to disadvantages such as low mechanical resistance, high viscosity, rapid enzymatic degradation and low solubility, GEL is generally combined with other polymers to improve its mechanical properties and promote the biocompatibility of these polymers [10]; in this case, a mixture of GEL with PVP was made
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