Abstract
This study aims to develop an active wound dressing material from polycaprolactone /silk fibroin (PCL/SF) blend nanofibers and curcumin (CU), as a therapeutic agent. PCL is a widely used polymer in biomedical application, but its hydrophobic characteristic restricts its use in wound dressings. SF was blended with PCL in order to overcome this limitation. Results showed that SF improved the water take up capacity and hydrophilicity of PCL nanofibers, but also decreased their strength. When CU was added to spinning solution of PCL/SF nanofibers average fiber diameter increased dramatically. Nanofibers became more hydrophilic, but also weaker. In-vitro release study revealed that a burst release of CU from nanofibers within first 3 hours followed by a sustained slow release up to 240 hours.
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