Abstract
In this work, composite membranes were investigated as future components of a layered implant for the reconstruction of nasal septum. Incorporation of zinc ions into nasal implants could potentially provide antibacterial properties to decrease or eliminate bacterial infections and subsequent surgical complications. Two types of membranes were prepared using an electrospinning method: PCL with bioglass and PCL with bioglass doped with Zn. The aim of this work was to investigate the influence of bioglass addition on the morphology, fiber diameter and composition of the membranes. The apatite-forming ability was examined in Simulated Body Fluid (SBF). The cytotoxicity of the membranes, ALP activity and in vitro mineralization were evaluated in cell culture. The mineralization and ALP activity was higher for polycaprolactone membranes modified with Zn doped bioglass than compared to pure PCL membranes or control material. The results proved that the presence of Zn2+ in the electrospun membranes = influence the osteogenic differentiation of cells.
Highlights
Injuries of nasal bone and cartilage are important issues for the patients and for laryngologists and plastic surgeons [1]
The microstructure of PCL membranes were influenced by the bioglass size and parameters of the electrospinning process
It has been shown that 4% wt. of A2 BG concentration in the solution permits formation of membranes with uniform fiber diameter distribution
Summary
Injuries of nasal bone and cartilage are important issues for the patients and for laryngologists and plastic surgeons [1]. Its applicability is limited by the finite availability and donor postoperative pain. Considering these disadvantages, the use of alloplasts in rhinoplastic or septoplastic procedures seems to be extremely attractive because of the lack of donor site morbidity, unlimited availability, ease of contouring, and relative simplicity of insertion. Bacteria can adhere to and colonize the biomaterial surfaces, leading to serious implant infection. Complications from infections and aggressive foreign body reactions sometimes lead to extrusion and damage of overlying tissue [7]
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