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Abstract
Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.
Highlights
Atopic dermatitis (AD) is a chronic, inflammatory skin disease affecting numbers of children and adults, with worldwide prevalence ranging from 0.2%–24.6% [1]
Our results demonstrated that PCL fibers show high tensile strength and strain properties
We showed that oil release and spreading strongly depend on fiber morphology and orientation affecting skin moisturization
Summary
Atopic dermatitis (AD) is a chronic, inflammatory skin disease affecting numbers of children and adults, with worldwide prevalence ranging from 0.2%–24.6% [1]. Different drug delivery systems including nanoparticles, cryogel-based formulations, microneedle patches, and nanoemulsions were developed in pharmaceutical and cosmetic industries to treat it [5]. Skin patches gain a lot of interest in cosmetic, topical, and transdermal delivery systems, being classified into the reservoir systems and the drug dissolved or dispersed in an adhesive layer. The drug is dissolved or dispersed in a reservoir, where the release rate is controlled by a membrane or matrix. In the second sub-type, the drug is dissolved or dispersed in an adhesive layer which is in contact with the skin [6]. Scaffolds, and patches have been widely utilized in tissue engineering [7,8,9], hemostats [10], tendon repair [11], drug delivery systems for wound healing [12,13], and in the face masks applications [14,15]
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