Abstract
ABSTRACTThe aim of the present work was to introduce the novel and convenient nanoapproach for more effective control of psoriasis. In this study, the polyacrylonitrile (PAN)-based electrospun fiber-loaded hydrocortisone was prepared with a topical electrospinning process. The results showed that the nanofibers had a smooth surface with an average diameter of 288.62 ± 46.42, 195.96 ± 35.60, and 160.11 ± 30.11 and the tensile stress of 1.74, 3.77, and 15.35 MPa for PAN, PAN with 1 and 5% Tween 80, respectively. The amorphous dispersion of hydrocortisone in the nanobandage was proved by X-ray diffraction and differential scanning calorimetry study. The presence of Tween 80 increased drug released to completely 100% in investigated period with positive effect. The cytotoxicity study proved the noncytotoxicity of fibers against human umbilical vein endothelial cell line.
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