Abstract
Traditional wound dressings require frequent replacement, are prone to bacterial growth and cause a lot of environmental pollution. Therefore, biodegradable and antibacterial dressings are eagerly desired. In this paper, gelatin/ZnO fibers were first prepared by side-by-side electrospinning for potential wound dressing materials. The morphology, composition, cytotoxicity and antibacterial activity were characterized by using Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), particle size analyzer (DLS), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermogravimetry (TGA) and Incucyte™ Zoom system. The results show that ZnO particles are uniformly dispersed on the surface of gelatin fibers and have no cytotoxicity. In addition, the gelatin/ZnO fibers exhibit excellent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) with a significant reduction of bacteria to more than 90%. Therefore, such a biodegradable, nontoxic and antibacterial fiber has excellent application prospects in wound dressing.
Highlights
Skin, as the human body’s largest organ, exerts a vital role in protecting the human body from external harm
Traditional cotton gauze needs to be replaced frequently, and adheres to the wound, which can lead to secondary tissue trauma and bacterial breeding [4–6]
The data indicate that ZnO particles can be uniformly dispersed on the surface of gelatin fibers
Summary
As the human body’s largest organ, exerts a vital role in protecting the human body from external harm. Skin damage can lead to microbial invasion of the human body, resulting in a threat to human health [1–3]. Medical dressing is a kind of medical equipment which can cover damaged skin and form a microenvironment conducive to wound healing, playing an effective role in wound care and treatment. Most medical dressings still use traditional cotton gauze. Traditional cotton gauze needs to be replaced frequently, and adheres to the wound, which can lead to secondary tissue trauma and bacterial breeding [4–6]. Huge dressing wastes cause great harm to the environment. It is urgent to design new biodegradable and biocompatible dressing materials with good antimicrobial activity
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