Abstract
Burns are a major threat to public health and the economy due to their costly and laborious treatment and high susceptibility to infection. Efforts have been made recently to investigate natural bioactive compounds with potential use in wound healing. The importance lies in the capacities that these compounds could possess both in infection control by common and resistant microorganisms, as well as in the regeneration of the affected tissues, having in both cases low adverse effects. However, some bioactive molecules are chemically unstable, poorly soluble, and susceptible to oxidative degradation or have low bioavailability. Therefore, developing new technologies for an efficient treatment of wound healing poses a real challenge. In this context, electrospun nanofibers have gained increasing research interest because bioactive molecules can be easily loaded within the nanofiber, resulting in optimal burst control and enhanced drug stability. Additionally, the nanofibers can mimic the extracellular collagen matrix, providing a suitable highly porous structural support for growing cells that facilitate and accelerate skin burns healing. This review gives an overview of the current state of electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment.
Highlights
Published: 1 December 2021Burns remain a major public health problem globally, resulting in increasing numbers of disabilities and preventable deaths each year
Efforts have been made to investigate a range of natural bioactive compounds that have been traditionally used as curative agents, in addition to others that have been reported as having potential use in dermatology, in the area of wound and burn healing [3]
Zhou et al [55] developed a membrane of electrospun fibers of PCL, chitosan oligosaccharides and quercetin/rutin, which has the potential to eliminate reactive oxygen species produced by inflammatory reactions; the antioxidant and antibacterial activities of quercetin/rutin may prevent wound healing being retarded by infections
Summary
Burns remain a major public health problem globally, resulting in increasing numbers of disabilities and preventable deaths each year. Pharmaceutics 2021, 13, 2054 of treatments for burns, the importance lies in the capacities they could possess both in the control of infections by common and resistant microorganisms and in the regeneration of the affected tissues, having in both cases low adverse effects. Some of these bioactive compounds are chemically unstable, poorly soluble, susceptible to oxidative degradation, or have low bioavailability [5]. The main of the present work was to analyze and categorize the physicochemical and structural properties of electrospun fibers with therapeutic potential for the treatment of skin burns, the polymers used, and the natural bioactive compounds encapsulated
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