Abstract
The ultimate goal in tissue engineering is to fabricate a scaffold which could mimic the native tissue structure. In this work, the physicochemical and biocompatibility properties of electrospun composites based on polyurethane (PU) with added pepper mint (PM) oil and copper sulphate (CuSO4) were investigated. Field Emission Electron microscope (FESEM) study depicted the increase in mean fiber diameter for PU/PM and decrease in fiber diameter for PU/PM/CuSO4 compared to the pristine PU. Fourier transform infrared spectroscopy (FTIR) analysis revealed the formation of a hydrogen bond for the fabricated composites as identified by an alteration in PU peak intensity. Contact angle analysis presented the hydrophobic nature of pristine PU and PU/PM while the PU/PM/CuSO4 showed hydrophilic behavior. Atomic force microscopy (AFM) analysis revealed the increase in the surface roughness for the PU/PM while PU/PM/CuSO4 showed a decrease in surface roughness compared to the pristine PU. Blood compatibility studies showed improved blood clotting time and less toxic behavior for the developed composites than the pristine PU. Finally, the cell viability of the fabricated composite was higher than the pristine PU as indicated in the MTS assay. Hence, the fabricated wound dressing composite based on PU with added PM and CuSO4 rendered a better physicochemical and biocompatible nature, making it suitable for wound healing applications.
Highlights
The largest organ in the human body is skin which plays a critical role in homeostasis and inhibits microorganism invasion
The cell viability of the fabricated composite was higher than the pristine PU as indicated in the MTS assay
This work successfully evaluated the physicochemical and biocompatibility properties of electrospun composites based on polyurethane (PU) added with pepper mint (PM) oil and copper
Summary
The largest organ in the human body is skin which plays a critical role in homeostasis and inhibits microorganism invasion. A wound is an injury to the skin when the skin tissue gets damaged. Once the skin gets affected, it should be treated immediately, otherwise it can cause acute pain, serious infections, and wound burden [1]. The treatment for the damaged skin involves the use of wound dressing which acts as a skin barrier and aids wound healing [2]. An Rideal wound dressing should be biocompatible, non-allergic, providing a moist environment, facilitates gas exchange, adsorbs exudates, and reduces pain and risk of infection [3].
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