Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug.

Yubo Liu,Yuyang Liu,Yuhang Gao,Ping Liu,Xiaohong Chen

doi:10.3390/polym14030469

Yubo Liu, Yuyang Liu + Show 3 more

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https://doi.org/10.3390/polym14030469

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Journal: Polymers	Publication Date: Jan 24, 2022
Citations: 40	License type: CC BY 4.0

Affiliation: University of Shanghai for Science and Technology

Abstract

In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic F1 fibers and coaxial F2 fibers were successfully prepared using polyvinylpyrrolidone as the main polymer matrix for drug loading and the poorly water-soluble curcumin (Cur) as a model drug. The hydrophobic poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) was designed as a blank layer to change the hydrophilicity of the fiber and restrain the drug dissolution rate. The curved linear morphology without beads of F1 fibers and the straight linear morphology with few spindles of F2 fibers were characterized using field-emission environmental scanning electron microscopy. The amorphous forms of the drug and its good compatibility with polymeric matrix were verified by X-ray diffraction and attenuated total reflectance Fourier transformed infrared spectroscopy. Surface wettability and drug dissolution data showed that the weaker hydrophilicity F2 fibers (31.42° ± 3.07°) had 24 h for Cur dissolution, which was much longer than the better hydrophilic F1 fibers (15.31° ± 2.79°) that dissolved the drug in 4 h.

Highlights

Academic Editors: Alejandro SosnikIn recent years, drug delivery systems have attracted widespread attention due to their ability to deliver the correct number of drugs to the proper place [1,2,3,4,5], especially for poorly soluble drugs
Trading Co., Ltd. (Shanghai, China). 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP, C3 H2 F6 O, 99%), ethanol, curcumin, Tween 80, and phosphate-buffered saline (PBS) buffer were purchased from Sinopharm Chemical Reagent Co., Ltd. (Shanghai, China)
1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP, C3H2F6O, 99%), ethanol, curcumin, Tween 80, and phosphate-buffered saline (PBS) buffer were purchased from Sinopharm Chemical

Summary

Introduction

Academic Editors: Alejandro SosnikIn recent years, drug delivery systems have attracted widespread attention due to their ability to deliver the correct number of drugs to the proper place [1,2,3,4,5], especially for poorly soluble drugs. Many drug delivery systems are exploited to improve the bioavailability of poorly soluble drugs, such as nanoparticles [9,10,11,12,13], hydrogels [14,15], 3D printing [16,17], electrospun fibers [18,19,20,21], nanocapsules [22], and microspheres [23]. The diameter of fibers generally ranges from tens of nanometers to several micrometers due to the influence of polymers, solvents, and other external conditions [28]. During this process, drugs are fixed on homogeneous fibers without destroying its own active molecular structure. The required drug dissolution process can be customized in accordance with the composition and structure of the fibers, thereby manipulating the controlled dissolution of the drug [7,29,30,31]

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