Abstract
Modern drug delivery systems demand the development of targeted polymer-carriers with the set of obligatory requirements. Thus, such capsules must have total biocompatibility, biodegradability, and possess non-allergenic, and non-tumorigenic properties. Hyaluronic acid (HA), as a natural linear polysaccharide that is included in the pericellular and extracellular matrixes, satisfies all these demands in the best possible way. In this study, the biopolymer nanoparticles with an average diameter of 300 nm were successfully obtained from aqueous HA solutions by electrospraying technique and characterized. Due to the presence of active functional groups in the structure of HA, such polymer particles can incorporate various pharmaceutical agents. This finding expands the investigation and subsequent application of drug-loaded nanoparticles based on HA as challenging and advanced targeted delivery systems.
Highlights
Hyaluronic acid (HA) is a linear glycosaminoglycan that consists of regularly alternating residues of D-glucuronic acid and N-acetyl-D-glucosamine with a molecular weight of 5–20,000 kDa [1]
Thereby, electrical conductivity is considered as a unique required parameter for electrospinning and electrospraying techniques and biomaterials obtained by these methods
Biopolymer nanoparticles based on native hyaluronic acid, for the first time, were successfully obtained by electrohydrodynamic jetting from distilled water solutions at ambient conditions
Summary
Hyaluronic acid (HA) is a linear glycosaminoglycan that consists of regularly alternating residues of D-glucuronic acid and N-acetyl-D-glucosamine with a molecular weight of 5–20,000 kDa [1]. It can be found in various tissues and fluids, and in the greatest quantities, it is present in skin, articular cartilage, and synovial fluid [2]. Hyaluronic acid performs structural functions and plays an important role in the processes of inflammation, tissue regeneration, and immunosuppression [5]. Due to its unique biological and physicochemical properties, HA is actively investigated as a promising biomaterial for various medical, pharmaceutical, food, and cosmetic applications.
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