Abstract
Fenofibrate is widely used as a lipid-lowering drug. However, fenofibrate has a short half-life, so it needs to be prepared as a sustained-release preparation to prolong the administration time. In this study, fenofibrate nanofibers are prepared by electrospinning using the biodegradable material polylactic acid as a drug carrier. To improve the hydrophilicity and cumulative drug release rate, polyvinylpyrrolidone is introduced to prepare a composite drug-loaded nanofibrous membrane. The experimental results show that the hydrophilicity and cumulative release rate are improved. This study provides a simple and efficient method for the preparation of fenofibrate nanofibrous membranes with sustained-release effects.
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