Electroporation in Cancer Therapy: A Simplified Model Derived from the Hodgkin-Huxley Model.

Abstract

Cancer remains a global health challenge, necessitating effective treatments with fewer side effects. Traditional methods such as chemotherapy and surgery often have complications. Pulsed electric fields and electroporation have emerged as promising approaches to mitigate these challenges. This study presents a comprehensive overview of electroporation as an innovative tool in cancer therapy, encompassing critical elements such as pulse generators and delivery devices. Furthermore, it introduces a simplified reversible electroporation model grounded in the Hodgkin-Huxley model. This model ensures resting potential stability by regulating ionic currents. When membrane charges reach the electroporation threshold, the model swiftly increases the fraction of open pores, resulting in a rapid rise in electroporation current. Conversely, as the transmembrane potential drops below the threshold, the model gradually reduces the fraction of open pores, leading to a gradual decline in electroporation current, indicating pore resealing. This model contributes to easier modeling and implementation of reversible electroporation dynamics, providing a valuable tool for further exploration of electroporation for cancer therapy.