Abstract
The present study was undertaken to elucidate how the plastic properties of model membranes from native lipids of different tissues of rats change in the course of Macrovipera lebetina obtuse (MLO), Montivipera raddei (MR) and Naja kaouthia (NK) venoms processing. The presence of viper venom in organism lead to increasing of the electrical resistance of BLMs from liver and muscle lipids approximately on a sequence, while the BLMs from brain lipids has not shown a noticeable differences of plastic properties compare the control. The same concentration of cobra venom leads to decreasing of electrical resistance of BLMs from 1011 Ohm till 108 Ohm. The low concentration of venom leads to appearance of channel activity. Especially it is noticeable in liver lipids in media of bivalen ions.
Highlights
As Vipers and pit vipers produce venoms, which contain proteins that are normally part of the coagulation cascade, the normal haemostatic system and can cause tissue repair
The venom of the Macrovipera lebetina obtusa, Montivipera raddei and Naja kaouthia was tested for its ability to induce supramolecular changes in rats after short-term (10 min) intramuscular injection of the venom (0.35 mg/kg approx. 0.5 LD50), by modeling of artificial membranes from native lipid content from some organs
After a few minutes of equilibration, –100 mV potential was applied in order to monitor changes in electrical properties of bilayer lipid membrane (BLM)
Summary
As Vipers and pit vipers (snakes of the family Viperidae) produce venoms, which contain proteins that are normally part of the coagulation cascade, the normal haemostatic system and can cause tissue repair. Angiogenesis, the process by which new blood vessels are formed, is a fundamental event required for a number of physiological and pathological conditions and the crucial role of cell extracellular matrix communication in angiogenesis is well established [6,7]. Because of their unique biological effect, many types of snake’s venom have been utilized as valuable pharmacological reagents for studies on the interacttion of their content and organized lipid interfaces, like as BLMs, LUVs, SUVs MLVs etc. It is generally accepted that secreted (integral) enzymes are active in the presence of transient “membrane defects” which have been identified as the borders between coexisting lipid phases [10,11]
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