Abstract
目的 探讨成年大鼠一侧全臂丛根性撕脱伤后双侧初级体感皮层可塑性变化的规律.方法将30只SD雄性大鼠分为6组,分为正常对照组和全臂丛根性撕脱伤术后1 d、7 d、1个月、3个月、1年共5个时间组,每组5只.采用体感皮层诱发电位(somatosensory evoked potential,SEP)记录法,定量评价一侧全臂丛根性撕脱伤后双侧初级体感皮层(Sm1)可塑性变化的时程.结果术后不同时间段电刺激患爪正中神经支配区,在双侧Sm1 均未诱发出SEP.电刺激健侧前爪正中神经支配区,在健爪同侧Sm1未记录到SEP,只在其对侧Sm1记录到SEP;但不同时间段的SEP位点数目均明显多于正常对照组.结论成年大鼠的初级体感皮层仍具有可塑性,一侧全臂丛根性撕脱伤后诱发了双侧Sm1动态的功能重组.两大脑半球相对应的同位区域之间存在着维持半球间平衡和协调的特殊机制.健侧前爪体感代表区的扩大可提高健爪的感觉辨别能力,以部分代偿患肢感觉功能的丧失。
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