Abstract
We studied the effects of mianserin on the action potentials of papillary muscle from the guinea-pig. Mianserin (above 10μM) reduced the maximum rate of the rise (⊢otV max) of the action potential, and shifted the ⊢otV max E m relationship to more negative potentials. The compound also depressed the slow action potentials of K +-depolarized papillary muscles. It is concluded that relatively high concentrations of mianserin had an inhibitory action on the electrophysiological properties of both the fast- and slow-response fibers of the heart.
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