Abstract
The reception of various groups of chemical stimuli (nicotine and certain acids) was studied in conditions of deranged metabolism of intestinal tissue under the influence of various doses of monoiodoacetic acid. Experiments were performed with perfusion of an isolated portion of intestine connected to the organism by nerves alone. As the effect of monoiodoacetic acid becomes more pronounced the increase of the afferent impulse flow ceases and reflex changes of the blood pressure disappear. Reactions of nicotine are re-established, the afferent flow increase and the reflex changes of the blood pressure recur after washing in Ringer-Locke's solution. At the same time, administration of acid depresses the impulse flow and causes depressive reactions of the blood pressure. The conclusion was reached that the mechanisms blocked by monoiodoacetic acid evidently take no part in reception of nicotine and drugs with a similar effect. The reception of acids is impossible after specific block of these mechanisms.
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