Abstract
Neocortex from 17–18-day rat embryos was transplanted into the barrel-field cortical area in adult rats. Neuronal response to deflecting the vibrissae was tested in the graft 3–8 months afterwards. Nine out of 11 grafts showed a response to sensory stimulation. Irregular and asynchronous discharges predominated in neuronal background firing activity in these grafts. Generalized slow-wave activity had much in common with that occurring on the diametrically opposite site on the intact host brain cortex. Hypersynchronous volleys were detected in neurons of unresponsive grafts. A predominance of waves within the delta range while other rhythms remained only faint, together with epileptiform sharp spikes were seen in generalized activity. Histological treatment of responding grafts revealed close fusion between tissue and host brain. Non-responsive grafts were surronded by a thick glial scar.
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