Abstract
Several domains of cognitive function, e.g., verbal memory, information processing, fluency, attention, and executive function are impaired in patients with schizophrenia. Cognitive impairments in schizophrenia have attracted interests as a treatment target, because they are considered to greatly affect functional outcome. Electrophysiological markers, including electroencephalogram (EEG), particularly, event-related potentials, have contributed to psychiatric research and clinical practice. In this review, we provide a summary of studies relating electrophysiological findings to cognitive performance in schizophrenia. Electrophysiological indices may provide an objective marker of cognitive processes, contributing to the development of effective interventions to improve cognitive and social outcomes. Further efforts to understand biological mechanisms of cognitive disturbances, and develop effective therapeutics are warranted.
Highlights
Cognitive impairments are considered as a fundamental feature of schizophrenia [1]
This paper provides selective reviews of studies on the relationships among cognitive function, electrophysiological findings, and treatment response in patients with schizophrenia
Using three dimensional images of current density of Event-related potentials (ERPs) in the brain, we reported the ability of treatment with olanzapine for 6 months to enhance P300 current density in the left STG, yielding a distribution pattern of the current density similar to that in healthy control subjects [68]
Summary
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan Reviewed by: Kesong Hu, DePauw University, United States Atsuhito Toyomaki, Hokkaido University, Japan Specialty section: This article was submitted to Psychopathology, a section of the journal Frontiers in Psychiatry
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