Electrophysiological effects of EGIS-7229, a new antiarrhythmic agent, in isolated guinea pig papillary muscle

Abstract

1. 1. The cellular electrophysiological effects of EGIS-7229, a novel antiarrhythmic agent, were studied in guinea pig papillary muscles with the use of conventional microelectrode techniques. 2. 2. The drug had a concentration-dependent biphasic effect on action potential duration (APD). APD was significantly lengthened at low concentration (3 μmol/l), whereas it was shortened at concentrations higher than 10 μmol/l. 3. 3. At concentrations higher than 10 μmol/l, the drug decreased the maximum velocity of action potential upstroke ( V max), the force of contraction, and altered the restitution kinetics of APD. 4. 4. The effect of EGIS-7229 on V max was frequency dependent; it was most prominent at short pacing cycle lengths (use-dependent block). 5. 5. On the basis of present results, EGIS-7229 appears to carry mixed class I and class III characteristics. Class III properties are present at low concentrations, whereas, at higher concentrations, class I actions may be predominant.