Abstract
An extract obtained from the leaves of Ageratum conyzoides L. changed the electrocardiogram, atrial impulse velocity, and coronary vessels resistance on isolated guinea-pig heart. Electrocardiographic alterations were:(a) PR interval increased from 80 ± 1.4 ms to 105 ± 14 ms (p < 0.01);(b) QT interval decreased from 170 ± 2 ms to 154 ± 7 ms (p < 0.01);(c) heart rate decreased from 170 ± 17 bpm to 152 ± 21 bpm (p < 0.01);(d) atrial impulse velocity decreased from 51 ± 2 cm/s to 45 ± 3 cm/s (p < 0.01);(e) the time spent for the impulse to be conducted from the atrium to the His bundle increased from 73 ± 13 ms to 100 ± 24 ms (p < 0.01);(f) aortic pressure decreased from 32 ± 4.8 cmH2O to 28 ± 5.1 cmH2O (p < 0.01). These effects disappeared after a washout. Copyright © 1999 John Wiley & Sons, Ltd.
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