Abstract
Fourteen male Sprague-Dawley rats were implanted with recording electrodes in both the mesencephalic reticular formation (MRF) and the anterior polysensory cortex. After recovery, they were trained in a state-dependent learning paradigm utilizing a two-way shuttle avoidance procedure. We found that the animals trained under 15 mg/kg sodium pentobarbital learned the task faster than the saline-trained animals. Both recording sites showed a frequency difference between avoidance trials and error trials. Only the MRF showed a significant change in frequency at the onset of a trial. After criterion was reached, the animals were given overtraining trials. It was found that transfer to the opposite drug state was related positively to the amount of overtraining given. The MRF frequency in the test situation showed a difference between trials in which there was a response and those in which there was not. These results are discussed in relation to John’s hypothesized circuits mediating the retrieval of memory.
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