Electrophysiological Characterization of Purkinje Cells from FHM3 (SCN1A) Knock-In Mice

Abstract

Migraine is a particularly severe form of headache which arises in only one side of the head and affects women (13-20%) more often than men (3-14%). Familial hemiplegic migraine type 3 (FHM3) is a rare autosomal dominant genetic disease, whose major symptoms are severe migraine, hemiparesis and aura. FHM3 is caused by mutations in the gene coding for the voltage-dependent sodium channel Nav1.1, whose activity is responsible for the generation and transmission of the fast electrical signals used by neurons to communicate across long distances.