Abstract
The plasma ceruloplasmin of 22,367 children of A-bomb survivors in Hiroshima and Nagasaki was examined for variants by electrophoresis. The sample was composed of 14,964 unrelated children and 7,403 siblings of the unrelated persons. A total of seven types of electrophoretic variants were detected; four migrating anodally and three cathodally to the normal B band. We have reported two of these variants, CP ANG1 and CP CNG1, previously but the other five, CP ANG2, CP AHR1, CP AHR2, CP CHR1, and CP CHR2, are newly identified. The allelic frequency ofCP*CNG1 was 0.00916, so that the variant is considered to be a polymorphic allele. Homozygosity for theCP*CNG1 allele was detected in five individuals. This is the first report of a homozygous phenotype for a ceruloplasmin variant in a Japanese population. Family study of the new five variants all demonstrated patterns of codominant inheritance.
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Schedule a callMore From: Jinrui idengaku zasshi. The Japanese journal of human genetics
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