Abstract
The distribution of radiothyroxine and radiotriiodothyronine in the electrophoretic pattern of normal and thyroglobulin- immune guinea pig sera was studied by both agar and paper electrophoresis. In normal or only adjuvant-treated animals, both thyroxine and triiodothyronine migrated to the albumin region. With thyroglobulin-immune sera, however, an additional peak of radioactivity was obtained in the beta-gamma globulin region as well as the one in the albumin region. The area covered by the peak of radioactivity in the beta-gamma globulin region differed in individual guinea pigs, presumably in relation to the level of circulating antibody, and could be inhibited by pretreating the immune serum with stable thyroxine. A precipitation reaction was obtained by layering a thyroglobulin solution onto immune serum but no precipitation reaction could be elicited with thyroxine or triiodothyronine. No radioactivity peak in the beta-gamma globulin region could be obtained with I131- labeled diiodotyrosine, radio...
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
