Abstract

To clarify the biochemical characteristics of nerve tumors, we studied esterase isozymes in the extracts of normal nerve tissue, neurinomas, neurofibromatosis and neurogenic sarcomas.Esterase isozymes were separated on polyacrylamide gel and were stained by the simultaneous azo dye coupling method as previously described.Normal nerve tissue, neurinomas and neurofibromatosis could be recognized and distinguished by means of their specific isozyme patterns.However isozyme pattern of neurogenic sarcoma showed some resemblances to that of neurinoma, esterase activity in band F of neurogenic sarcoma seemed to be much higher than that of neurinoma. Our preliminary data suggest the possibility of chemical diagnosis of nerve tumors.

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