Abstract
AbstractThe cell electrophoretic mobility of polymorphonuclear leukocyte responses to scale extracts from psoriasis vulgaris and other dermatoses (callus and pompholyx) was determined by analytical free‐flow cell electrophoresis technique. Incubation with scale extracts from psoriasis significantly reduced the electrophoretic mobility of polymorphonuclear leukocytes compared with those from callus and pompholyx; ultrafiltrated scale extracts separated 10,000–30,000 d showed the highest reduction. Pretreatment of polymorphonuclear leukocytes with etretinate in vitro blocked reduction of the cell electrophoretic mobility. It is concluded that psoriatic scale extracts contain factor(s) which reduce the charge density of polymorphonuclear leukocytes and that this reduction is inhibited by etretinate pretreatment.
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