Abstract
Genetic polymorphism of the A and B subunits of coagulation Factor XIII has been detected using thin layer agarose electrophoresis, together with fluorescent and immunochemical staining techniques. Each subunit is the product of an autosomal locus. In Australian blood donors the locus for the A subunit has two alleles (gene frequency: F-XIIIA 1 , .8; F-XIIIA 2 , .2) while the locus for the B subunit has three alleles (gene frequency: F-XIIIB 1 , .75; F-XIIIB 2 , .08; F-XIIIB 3 , .17). Study of a family with inherited Factor XIII deficiency indicated the deficiency was due to the inheritance of a null allele at the locus for the A subunit (F-XIIIA 0 ) . Individuals heterozygous for this allele connot be detected by electrophoresis since they appear to be homozygous for either the F-XIIIA 1 or F-XIIIA 2 alleles. Determinations of thrombin activated transamidating activity in plasma have shown that the commonly inherited forms of the A subunit of Factor XIII do not differ significantly. This finding suggests that the A subunit polymorphism may have little functional significance.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
