Abstract
Various species of hydroxyethyl-starch (HES) has been developed for use in the management of hypovolemia, and intravenous infusion of HES results in iatrogenic macroamylasemia. Clinically, recognition of macroamylasemia is important to distinguish them from other conditions that are attended by hyperamylasemia. Electrophoresis is a generally appricable test for detection of naturally occuring macroamylase, however, there is no information of about the detection of the iatrogenic macroamylase by electrophoretic analysis. We examined the serial amylase isoenzymes electrophoretic patterns of serum in 23 patients undergoing abdominal surgery. In them, 12 patients were dosed with 500-1, 000ml of 6% solution of the HES possessing a relative molecular mass of 30, 000-40, 000 combined with a molar hydroxyethyl group substitution of 0.50-0.55 upon operation. Electrophoretic analysis of the sera revealed that HES resulted in the characteristically anomalous electrophoretic pattern with cathodally migrating broaden amylase bands.
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