Electrooxidation of antihistamine drug methdilazine and its analysis in human urine and blood samples

Nagaraj P Shetti,Deepti S Nayak,Shikandar D Bukkitgar,Alexandra Martha Zoya Slawin

doi:10.1080/23312009.2016.1153274

Nagaraj P Shetti, Deepti S Nayak + Show 2 more

Open Access

https://doi.org/10.1080/23312009.2016.1153274

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Abstract

The electrochemical oxidation of an antihistamine drug, methdilazine, was studied in 9.2 pH with 0.2 M phosphate buffer as supporting electrolyte at 25 ± 0.2°C. Glassy carbon electrode was used to perform the experiment at cyclic voltammetry, linear sweep voltammetry and differential pulse voltammetric techniques. The dependence of the current on pH, concentration and scan rate were investigated. Differential pulse voltammetric technique was adopted to know the linear relation between peak current and methdilazine concentration. The linear response was obtained in the range of 3.0 μM–1.0 mM with a detection limit of 0.1 μM. The proposed method was also applied for the quantitative determination of methdilazine in pharmaceuticals and biological samples.

Highlights

A synthetic analogue of phenothiazine derivative (10-[(1-Methyl-3 pyrrolidinyl) methyl] phenothiazine monohydrochloride) known as Methdilazine hydrochloride (MDH), (Scheme 1) (Gordon, 1994) is used as an antihistamine and found to possess anti-pruritic action
We described the simple and quick tool for the direct determination of methdilazine hydrochloride, an antihistamine drug, at glassy carbon electrode
Electro-oxidation of methdilazine In order to understand the voltammetric behaviour of MDH, cyclic voltammetry method was utilised

Summary

Introduction

A synthetic analogue of phenothiazine derivative (10-[(1-Methyl-3 pyrrolidinyl) methyl] phenothiazine monohydrochloride) known as Methdilazine hydrochloride (MDH), (Scheme 1) (Gordon, 1994) is used as an antihistamine and found to possess anti-pruritic action. An overview of the improvement in electroanalytical chemistry demonstrates that solid metal electrodes represent the most rapidly rising class of electrodes (Jorge, Pontinha, Marques, & Oliveira-Brett, 2010; Shetti, Sampangi, Hegde, & Nandibewoor, 2009; Wudarska, Chrzescijanska, Kusmierek, & Rynkowski, 2013) Among all those electrodes, the utilization of glassy carbon electrode (GCE) for the electrochemical measurements has increased in recent years as they provide good sensitivity, negligible porosity and superior mechanical rigidity (Bukkitgar, Shetti, Kulkarni, & Nandibewoor, 2015; Hegde, Shetti, et al, 2009; Nayak, Shetti, & Katrahalli, 2015).

Materials and methods

Results and discussion

Analytical applications

Conclusion