Abstract
This study illustrates electrochemical behavior of hydroquinone and 4-amino-6-chlorobenzene-1,3-disulfonamide in the phosphate buffer solution evaluated by cyclic voltammetry. It was found that the peak of the hydroquinone oxidation potential in the presence of 4-amino-6-chlorobenzene-1,3-disulfonamide is shifted to more positive values compared to hydroquinone alone. Based on these results, the electrochemical synthesis of new disulfonamide substituted p-benzoquinone is proposed and carried out via electrochemical oxidation of hydroquinone in the presence of 4-amino-6-chlorobenzene-1,3-disulfonamide in the electrolytic cell. It has been concluded that hydroquinone is converted into disulfonamide substituted p-benzoquinone via an ECE mechanism. The successful electrochemical synthesis was conducted in the water/ethanol mixture under green conditions without any toxic reagents or solvents and with high atom economy.
Highlights
Electrochemistry provides a versatile way for electrosynthesis of biologically active intermediates and kinetic studies of different reagents that are of pharmaceutical importance [1]
1.0 mM solution of disulfonamide was put in the solution instead hydroquinone, not any peak was observed in the cyclic voltammogram recorded under same applied conditions
The results showed that E. coli has a little sensitivity to substituted disulfonamide p-benzoquinone
Summary
Electrochemistry provides a versatile way for electrosynthesis of biologically active intermediates and kinetic studies of different reagents that are of pharmaceutical importance [1]. Since electrochemical methods are simple and rapid, they are normally used to study electroactive compounds in pharmaceutical forms and physiological fluids. Quinones are classified in a large group of natural pigments that show excellent photochemical properties [2] and act as intermediates in a biosynthesis of important antibiotics [3]. Quinones exhibit biological activities such as antidiabetic [4] and are frequently used as charge transfer complexes [5]. The change from hydroquinone to quinine plays an important role in redox processes occurring in living organisms. Quinones act as electron–proton carriers for carrying oxygen in biochemical doi:10.5599/jese.555
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