Abstract
ObjectiveEffect of bilateral, optic neuropathy on the function of retinal pigment epithelium has not been investigated extensively to date. This study aimed to determine the effect of bilateral, optic neuropathy on light peak:dark trough ratio, light peak and dark trough values of electro-oculography. Thirty-seven patients with a clinical diagnosis of bilateral optic neuropathy and 40 control subjects were recruited in this observational, cross-sectional study, carried out at the Neurophysiology unit, Teaching Hospital, Peradeniya, Sri Lanka. Pattern reversal visual evoked potentials, pattern electroretinography and electro-oculography were recorded in all of them.ResultsTwenty-four patients (64.9%) had reduced light peak:dark trough ratio values. The median light peak:dark trough ratio ± inter quartile range of the patient group (1.50 ± 0.4) was significantly lower than that of the controls (1.80 ± 0.2), (p < 0.001). Median dark trough value was significantly higher in patients compared to the control value. These changes may be due to higher conductance of ion channels in the retinal pigment epithelium, sub retinal space creation, changes in choroidal circulation or secondary to photoreceptor abnormalities in the macular region. These results indicate that retinal pigment epithelium might be affected in bilateral optic neuropathy.
Highlights
Acute demyelinating optic neuropathy is a clinical diagnosis
These changes may be due to higher conductance of ion channels in the retinal pigment epithelium, sub retinal space creation, changes in choroidal circulation or secondary to photoreceptor abnormalities in the macular region
These results indicate that retinal pigment epithelium might be affected in bilateral optic neuropathy
Summary
Demographic and clinical characteristics There were 37 patients with bilateral optic neuropathy (15 (40.5%) males; median age: 47.0 ± IQR 23; range 18–70 years) in the test group and 40 subjects in the. Pattern reversal visual evoked potentials Median N75, P100 and N145 latencies in both eyes were significantly prolonged in patients with optic neuropathy when compared with the control group Pattern electroretinography There was no significant difference in median N35, P50 and N95 latencies and amplitudes of both eyes in the patients compared to the control group (see Additional file 1: Table S2). The median LP:DT ratio ± IQR of the patient group (1.50 ± 0.4) was significantly lower than that of the controls (1.80 ± 0.2) (Fig. 2). Median dark trough amplitude of the patient group was significantly larger than that of the controls (Fig. 1, Table 1)
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