Abstract
At present, about 30,000 derivatives of sulfanilamide are known. The establishment of a relationship between the structure of these compounds and their bacteriostatic activity is an urgent problem. In the present work, this problem is solved by means of NQR and NMR spectroscopy. Since the content of the /sup 14/N nuclei in these molecules is not high, to run the NQR, they used the double resonance method. Some samples of the sulfanilamides were studied by direct pulsed NQR method. The high resolution NMR spectra were run in heavy water solution on a RS-60MA spectrometer. All the measurements were carried out at 120/sup 0/K in the solid phase. The results of the calculation of eQq/sub zz/ for the NH/sub 2/ groups in the sulfanilamide residue are listed. To interpret the results by the MO LCAO method in the Hueckel approximation on the EC-1022 computer by a special FORTRAN program, they calculated the charged rho on an atom in the amino group with parameters of hetero atoms and coupling constants.
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