Abstract
To explore the applicability of fluorinated DNA components as radiosensitizing agents for cancer treatment, the electronic states of a nucleoside (FdU) and nucleotide (FdUMP) containing fluorine atom were investigated using X-ray photoelectron spectroscopy (XPS). The fluorine atoms significantly reduced the energy gap between the valence and conduction level of the nucleotide, although the core-level states of carbon or oxygen were not significantly affected by fluorination. This molecular nature is expected to facilitate reactions with radiolysis products, such as free radicals or low-energy secondary electrons, thus inducing reductive DNA damage with high efficiency in cancer cells.
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