Abstract
A microcomputer program using an electronic spreadsheet program was developed to calculate pharmacokinetic values of thiacetarsamide sodium, a drug used to kill the adult heartworm ( Dirofilaria immitis) parasite of the dog. A least squares, semilogarithmic regression analysis was done on data using a two compartment intravenous model. The data entered includes the time after injection and the drug concentration at that time. A graph of the points can be viewed or plotted, with the time on the x-axis, and the natural log of the drug concentration on the y-axis. The program was developed on a Televideo (512 kbytes) microcomputers ∗∗ ∗∗ Televideo 1605, MS-DOS, Sunnyvale, California, U.S.A. . The spreadsheet used was Lotus 123 ∗∗∗ ∗∗∗ Lotus 123, Lotus Development Corporation, Cambridge, Massachussetts, U.S.A. with the pharmacokinetics program occupying 16 kbytes of memory (720 cells) out of the 400 kbytes available with Lotus.
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