Abstract
The present work describes the spectrochemical study of some Lanthanide (III) - ceftazidime (Ln(III)-CEFZ) complexes. The impact of the ligand environment on electronic spectrum of the lantanide ion with special reference to complexation and nature of Ln-ligand bond has been examined. The energy and intensity parameters for the complexes have also been evaluated. The ligand and all prepared complexes were screened for their antibacterial activities against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and the results showed that antibacterial activity of ligand on complexation have been enhanced.
Highlights
Cephalosphorins antibiotics have been effectively used in various bacteria infected diseasesbecause of the presence of β-lactam ring [1, 2]
The Cephalosphorin class of antibiotics is classified into four generations, ceftazidime is a third-generation cephalosporin which demonstrates good activity against gram-negative organisms and some gram positive organism
In the present work, we have studied the physiochemical, spectral and antimicrobial properties of Lanthanide (III)-Ceftazidime complexes
Summary
Cephalosphorins antibiotics have been effectively used in various bacteria infected diseasesbecause of the presence of β-lactam ring [1, 2]. The Cephalosphorin class of antibiotics is classified into four generations, ceftazidime is a third-generation cephalosporin which demonstrates good activity against gram-negative organisms and some gram positive organism. It is effective for biliary-tract infections, bone and joint infections, cystic fibrosis (respiratory-tract infections), endophthalmitis, infections in immune compromised patients (neutropenic patients), meningitis, peritonitis, pneumonia, septicaemia, skin infections (including burns, ulceration) and urinary-tract infections [3]. Various strategies have been made to enhance the activity, or broaden the spectrum of these drugs, but the question about cost and adequacy of the supply, necessitate the use of novel agents [4]. The antibacterial activity of the metal complexes was found to be lower than that of free ceftazidime
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