Abstract
Changes in activity and localization of adenylcyclase were studied in rat heart perfused according to LANGENDORFF after N2-and CO-hypoxia and ischaemia. Under hypoxic conditions an increase of adenylcylase activity was found in the first minutes. Following 3 h nitrogen or 30 min CP perfusion the intensity of reaction was diminished. This later decrease of reaction intensity was not encountered under ischaemic conditions. Changes in localization were not observed either in hypoxia or in ischaemia. After reserpine or propranolol pre-treatment the posthypoxic/ischaemic initial activity-increase did not occur. It is assumed that the early increase in adenylcyclase activity (reaction intensity) following hypoxia/ischaemia is due to endogenous catecholamine release.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
