Abstract
The sodium salt of 1,3,6-trimethyl-5-nitrouracil is shown to react with various reductive alkylating agents such as p-nitrobenzyl chloride and dinitropropane by an S RN1 mechanism to give new potentially bioactive 5-nitrouracil derivatives. 1,3-Dimethyl-5-nitro-6-chloromethyluracil also reacts by an S RN1 mechanism with 2-nitropropane anion to afford a new uracil derivative bearing a trisubstituted ethylenic double bond at the 6-position.
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