Abstract
The halothane-derived peroxyl radical CF3CHClO2˙ has been generated in aqueous solutions by pulse radiolysis. Absolute rate constants for the reduction of halothane (2-bromo-2-chloro-1,1,1-trifluorethane) by hydrated electrons, hydrogen atoms, and propan-2-ol free radicals have been determined to be k 1.4 × 1010,3.8 × 108, and 7.6 × 107 l mol–1 s–1, respectively. The predominant product radical CF3ĊHCl rapidly adds O2, and an estimate of k 1.3 × 109 l mol–1 s–1, has been obtained for the absolute rate constant of this reaction. The resulting peroxyl radical CF3CHClO2˙ has been found to react rapidly with a variety of nucleophilic compounds such as 2,2′-azinobis(3-ethylbenzthiazoline-6-sulphonate), the phenothiazines promethazine, chlorpromazine, and metiazinic acid, the vitamins C and E, and propyl gallate. The absolute rate constants for these reactions are found to be generally lower than for corresponding reactions of the carbon tetrachloride-derived radical, CCl3O2˙.
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