Abstract
The interaction between lipopolysaccharide (LPS) and rat erythrocyte membranes was studied in vitro. The incubation of erythrocytes with LPS isolated from E. coli (J5 mutant) resulted in a decrease in membrane fluidity as determined by spin-label, electron spin resonance, and in the inhibition of Na+, K+-ATPase activity without remarkable alteration of the membrane lipid composition. The generation of hydroxy radicals was detected by spin-trap, electron spin resonance in the erythrocyte/LPS incubation medium. We suggest that changes in the dynamic properties of erythrocyte membranes were mediated by LPS itself and not indirectly by changes in the membrane lipid composition.
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